The MIIS Eprints Archive

Mathematical Models for Estimating the Risk of vCJD Transmission

Anvari, V. and Atapour, M. and Bourouiba, L. and Caudillo Mata, L. A. and Collinson, S. and Johnson, A. and Madras, N. and Miasnikof, P. and Ramirez Ramirez, L. L. and Sanchez-Bravo, I. (2009) Mathematical Models for Estimating the Risk of vCJD Transmission. [Study Group Report]



We present two different simple models for vCJD transmission by blood transfusion. Both models indicate that transfusions alone are unlikely to cause more than a few infections, unless the number of primary cases increases.

To improve our models, future work should pursue data collection, empirical estimation of the model parameters, and examination of the underlying assumptions of our frameworks.

Further improvements could also include examining susceptibility to vCJD infection by age group and iatrogenic infections introduced through surgical instruments. Regarding the latter, it may be worthwhile to conduct experiments to quantify the transmission of prions from an infected surgical instrument after repeated sterilization procedures.

Item Type:Study Group Report
Problem Sectors:Medical and pharmaceutical
Study Groups:Canadian Biomedical Problem Solving Workshop > 1st Canadian Biomedical Problem Solving Workshop (Toronto, Canada, Jun 22-26, 2009)
Company Name:Public Health Agency of Canada
ID Code:342
Deposited By: Dr Kamel Bentahar
Deposited On:27 Jul 2011 17:56
Last Modified:29 May 2015 19:57

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