The MIIS Eprints Archive

A Mechanism for Ventricular Expansion in Communicating Hydrocephalus

Begg, R. and Wilkie, K. (2009) A Mechanism for Ventricular Expansion in Communicating Hydrocephalus. [Study Group Report]



This report investigates a new possible molecular mechanism for the pathogenesis of hydrocephalus. New research by Dr. Miles Johnston has found that the injection of anti beta_1 integrin antibodies into the ventricle of rats causes a drop in parenchymal pressure and causes the cerebral ventricles to enlarge which is characteristic of hydrocephalus. We investigate intramantle pressure gradients as a possible force to enlarge the ventricles and we propose a new poroelastic model incorporating the effect of the antibodies to determine if they are a possible mechanism for hydrocephalus.

Item Type:Study Group Report
Problem Sectors:Medical and pharmaceutical
Study Groups:Canadian Biomedical Problem Solving Workshop > 1st Canadian Biomedical Problem Solving Workshop (Toronto, Canada, Jun 22-26, 2009)
Company Name:Sunnybrook Health Sciences Centre
ID Code:339
Deposited By: Dr Kamel Bentahar
Deposited On:27 Jul 2011 17:37
Last Modified:29 May 2015 19:57

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