Skeletal muscle fuel utilisation in healthy and disregulated states
Wattis, Jonathan
(2007)
Skeletal muscle fuel utilisation in healthy and disregulated states.
European Study Group with Industry > 59th ESGI [Nottingham 26/3/2007 - 30/3/2007].
Full text available as: | Item Type: | Study Group Report |
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| Study Group: | European Study Group with Industry > 59th ESGI [Nottingham 26/3/2007 - 30/3/2007] |
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| Company Name: | Unilever |
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| Industrial Sector: | Food and Drink
Medical and pharmaceutical |
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| Additional Contributors: | Pickersgill, Laura and MacDonald, Ian and Byrne, Helen and Hjorth, Poul and King, John and Lock, Anthony and Locsei, Tobias and McCullen, Nick and Miller, Joanne and Pitcher, Ashley and Ward, John |
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| ID Code: | 136 |
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| Deposited By: | Richard Booth |
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| Deposited On: | 20 May 2008 |
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Problem StatementIn healthy lean subjects, skeletal muscle displays metabolic flexibility, that
is, it is capable of switching between predominantly lipid oxidation with high
rates of fatty acid uptake during fasting conditions, and the suppression of
lipid oxidation in favour of increased glucose uptake, oxidation and storage
in response to insulin during the fed state. Insulin resistant states such as
obesity and Type 2 diabetes are characterised by this loss of, or reduction in,
fuel-switching ability. The aim is to develop a mathematical model of skeletal
muscle fuel utilisation, that will enable an investigation of the dynamics of
skeletal muscle glucose and lipid handling in response to a meal, as well as
the effects of insulin on these dynamics. Archive Staff Only: edit this record
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